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Modern Research:
現代研究﹕ |
Laboratory of Natural Products, Faculty of Medicine,
Chulabhorn Research Institute, Research Center at Chiangmai University,
Chiangmai University, Chiangmai 50200, Thailand. crujjana@med.cmu.ac.th
Gelsemium elegans Benth. (Loganiaceae), a toxic plant
indigenous to southeastern Asia, is well known among hilltribes as an
effective means for committing suicide. A crude alkaloidal fraction from its
leaves was isolated by conventional acid-base extraction. Tests in animals
showed that the alkaloids exerted analgesic and anti-inflammatory effects.
At a lethal dose, the alkaloids produced violent clonic convulsions that led
to respiratory failure. Since the convulsions could be prevented by
pentobarbital or diazepam and potentiated by reserpine, it is postulated
that the alkaloids act centrally against GABA action.
PMID: 14522437 [PubMed - indexed for MEDLI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14522437&dopt=Abstract |
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Toxicity & Cautions:
毒素與禁忌﹕ |
Whole plant is toxic. It is for
external use only. The young
leaves are especially toxic. There is no effective antidote. The commonly
used therapy is gastric lavage, promoting vomiting and diarrhea. See "Modern
Research" itme above.
全株有毒。只作外用。新生幼葉尤毒。沒有特效藥。一般處理方法﹕洗胃﹐催嘔﹐催瀉。看上條
“現代研究”。
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